Effect of coenzyme Q10 on neuropathic pain threshold resulting from spinal cord injury in male rats

Introduction: Coenzyme Q10 is a powerful antioxidant that has the ability to reduce the damage caused by oxidative stress and is predominantly found in the inner mitochondrial membrane. This study was conducted to determine the effect of coenzyme Q10 on neuropathic pain in an animal model of spinal cord injury. Methods: In order to induce neuropathic pain, thoracic segments of the spinal cord (T6-T8) were compressed by homeostatic clip. Two doses of coenzyme Q10 (50 and 100 μg) in a volume of 10 μl was injected intrathecally. Behavioural tests were conducted in the third week after injury. Allodynia and hyperalgesia symptoms were assessed using analgesiometer, von Frey filaments, acetone and plantar tests. Behavioral assessments were performed before and 15 min after the injections. Data were analyzed using SPSS 20.0 statistical software. Results: Coenzyme Q10 at the dose of 100 μg significantly attenuated the thermal hyperalgesia compared to vehicle and also compared to the pre-injection time (P< 0.05). In addition, administration of 100 μg of Q10 significantly reduced mechanical allodynia compared to the vehicle (P< 0.05). However, this reduction was not significant compared to the pre-injection time. Conclusion: Injection of coenzyme Q10 in the subarachnoid space alleviates some symptoms of neuropathic pain following spinal cord compression injury.